Job Details
Drug Discovery Research
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.
Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.
Position Responsibilities:
In the role as a Sr. Scientist within Discovery Pharmacology and In vivo Biology, the ideal candidate will:
Apply scientific, technical skills and functional knowledge to conduct in vivo pharmacology experiments and studies for immune-oncology drug discovery programs. Working closely with project teams and key stakeholders, design, execute and deliver in vivo studies from target concept to Proof of Concept in patients.
Characterize therapeutic candidates in vivo and build PK PD and efficacy relationship as part of the lead selection process.
Develop state of the art in vivo models, experimental protocols and relevant immune-oncology assays and employ innovative methods and technologies to test therapeutic hypotheses.
Work with cross-functional teams and participate in implementation of program strategy and translational strategies to support regulatory filings.
Execute experiments and deliver comprehensive high quality data sets to help decision making in a timely manner. Analyze results of complex experiments and present comprehensive technical or project reports at project team meetings.
Mentor and train junior level research associates.
Experience =
Basic Qualifications:
Bachelor’s Degree
7+ years of academic and / or industry experience
Or
Master’s Degree
5+ years of academic and / or industry experience
Or
Ph.D. or equivalent advanced degree in the Life Sciences
2+ of academic and / or industry experience
Preferred Qualifications:
Ph.D. or equivalent advanced degree in the Life Sciences with 2+ years of relevant academic and / or industry experience in immune-oncology and expertise in in vivo pharmacology.
Experience using cell line derived and/or patient derived xenograft mouse models, and syngeneic models to enable candidate selection is required.
Skilled and proficient at independently conducting model development, efficacy, PK/PD and combination studies and perform necropsy and tissue/blood collection.
Proficiency in cell culture, passaging and harvesting cells is required. Skilled at murine dosing via PO, IP, IV, SC routes.
Attention to detail with excellent organizational and record keeping skills is a requirement. Ability to work collaboratively across departments, understand and implement applicable regulations around animal care/safety/handling desired.
Extensive expertise with multi-parameter flow cytometry for immunophenotyping is highly desired.
Demonstrated expertise in ex-vivo assays such as MSD, ELISAs, qPCR, western blotting.
Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, etc. for data analysis and figure generation is required.
Excellent interpersonal and communication skills with the ability to interact effectively with internal colleagues is required.
#LI-Onsite
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
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