Job Search Results
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
•Health Care Professional (HCP) Interaction
Develop and maintain in depth and long-term peer-to-peer scientific relationships with external Thought Leaders based on their expressed needs to further understand and gain both insight and/or input into treatment patterns and share the insights internally as appropriate
b)Propose or conduct medical programs to deliver scientific information and present approved scientific data to HCPs
Involve in developing scientific presentations (e.g., abstracts or articles based on secondary data) under the guidance of the DAH/DAS/MSM Manager which presentation should be reviewed according to the appropriate internal review processes to ensure medical accuracy and ethical and legal compliance
d)Provide appropriate response and document the provision of accurate, approved scientific data in response to unsolicited scientific questions or requests posed by HCPs for disease area related products
•Collaboration with internal stakeholders
a)Provide medical support for promotional activities with presentation of scientific information, answering participants' questions within disease area or product-related information in a balanced manner
b)Liaise with the Medical Information team to provide ongoing scientific and medical support to the business, in particular by responding to queries
Work with appropriate BMS personnel to help ensure that all the information regarding SAEs in the field is collected to facilitate a correct and transparent communication of SAEs internally and to the competent Health Authorities Collaborate internally (with clinical operations team, DAS, etc.) to support clinical trial / study in compliance with related directives Prepare and/or contribute as appropriate to the initial and ongoing Medical / scientific disease area and product-specific training of internal BMS customers (sales force, etc.) – in collaboration with the training department, if any
•Contributor to Brand Plans & Strategies
a)Contribute to the development of brand plans and strategies by communicating medical insights and knowledge derived from HCPs or scientific publications about the product or disease area, in particular with reference to patient needs and treatment trends
•Compliance
a)Perform all of the above in an ethical and legally compliant manner
b)Follow company Policy and Procedure, country specific “Code of Conduct”, as well as required local authority requirement
1. 医药相关专业硕士及以上学历
2. 至少1年以上MSL相关工作经验
3. 肿瘤背景优先
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Clinical Development
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
Key Responsibilities and Major Duties
Develop and maintain oversight process for Clinical Operations deliverables
- Collaborate with cross-functional team to identify and drive adoption of innovative ideas/ solutions.Ensures consultation by Clinical Operations on the application of new technology and tools that are selected globally or locally to enable optimal use by investigative sites and/or by patients. This could include electronic Informed Consent Document applications, electronic Clinical Outcomes Assessment devices/applications, and the use emerging technology to support site level patient screening,remote/central monitoring for improving data qualityor study executioncompliance.
- Manage a quality improvement agenda of activities based on internal and external trends. Develop and lead oversight activities to ensure China RCO processes are in compliance with GDO and relevant BMS processes.
- Identify training needs for the organization based on business needs and trends, collaborate with SMEs to deliver the process training/refresh on a regular basis. Understand global and local processes, evaluate the risk/impact on China RCO, and take the lead of local implementation if appropriate.
- Network with cross-functional teams to onboard new service vendors while business needs evolve, continuous optimizing vendor onboarding to accelerate vendor contract execution with compliance with company policy.
- Develop team capability in vendor service oversight where required. Partner with study team to provide feedback to vendor for continous improvement where necessary
- Ensure system management capability within RCO functions. Acting as an expert function on system unitliation and oversight the system implementation locally with global enegagement, system including but not limited to Clincal platform, SIP, VeeVa eTMF, CDE Clinical Trial Registry.
Supports the planning and execution of quality activities for China RCO with internal and external partners
- Develops and maintains RCO process for China. The Quality Oversight and Capability Manager will maintain process and training in China to be aligned with Global BMS requirement/commitment.
- Participates directly in all quality planning activities with internal and external business partners. Additionally will interface with the quality function in any TPOs used by China clinical operations.
- Incorporates learning from issues management, inspections, and audit findings into materials and processes that improve the quality of clinical research execution at investigator sites. Ensures that CAPA is effectively implemented in the function through updates to working documents, forms, templates and instructions
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Drug Discovery Research
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS.
We are looking for an experienced, collaborative, highly motivated scientist and leader with deep expertise in antibody drug conjugates (ADC) technologies. The candidate should have deep understanding and experience antibody drug conjugation technologies. The candidate is expected to have strong collaborative skills to ensure robust partnerships with biologists, antibody discovery and engineering & bioanalytical scientists to advance ADC projects.
A prove track record of hands-on experience with antibody-drug conjugation chemistry, analytical characterization and developability of ADCs is a must have for this position.
Responsibilities:
- The role will involve leading and carrying out laboratory experiments related to ADC conjugation, associated purification and analytical characterization of the conjugates
- Design, produce, and characterize antibody-drug conjugates (ADCs) with a high degree of independence
- Proactively advise and share knowledge and expert opinions with bench scientists, peers and senior management. Mentor staff in troubleshooting strategic and experimental issues
- Record of leading project teams through different stages of pre-clinical discovery
- Ensure highest standard of quality in antibody-conjugate productions in alignment with product development guidelines and QC criteria
- Collaborate with a diverse team of biologists and chemists to answer scientific questions and drive forward new conjugation platforms
- Leverage knowledge of bioconjugation and protein engineering to develop new therapeutic ADC technologies.
- The candidate will encourage ideas for continuous improvement activities & new technology development and initiative within work group.
- Contribute to patents, publications, and technical reports.
Basic Qualifications:
Bachelor’s Degree with 8+ years of academic or industry experience
Or
Master’s Degree with 6+ years of academic or industry experience
Or
PhD with 4+ years of academic or industry experience
Preferred Qualifications:
A PhD with 4+ years of industry experience
Extensive hands-on experience with therapeutic antibody and ADC discovery
Deep knowledge of bioconjugation chemistries (lysine, inter-chain cysteine and/or site-specific cysteine and other) is needed.
Experience in development of purification strategies using various chromatographic techniques such as affinity, size exclusion, ion-exchange, hydrophobic interaction, and tangential flow filtration (TFF)
Experience in analytical characterization of ADCs including SEC, RP-HPLC, LC-MS, CE-SDS, ELISA, DSC, and HIC
Experience with biological assays such as measuring cytotoxic activity for ADC characterization.
Hands-on experience with siRNA/ASO conjugations and analytics is a plus.
Demonstrated record of scientific accomplishments and publications.
Excellent written and oral communication skills and ability to interpret results and contribute to multidisciplinary biologics discovery teams
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Drug Discovery Research
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
We are seeking an energetic and versatile protein scientist to join our Protein Production and Quality Attributes group. The ideal candidate is experienced with state-of-the-art approaches for high-throughput biotherapeutic production of antibodies, multi specifics, fusion proteins, and recombinant proteins. You will lead and manage the high-throughput production team supporting the BMS biotherapeutic pipeline from the bench in this lab facing role. Your hands on expertise with varied high throughput liquid handing platforms applied to protein production at various scales and technologies for production is essential for success. Priority will be given to candidates experienced in additional stages upstream and downstream of the production process including but not limited to protein engineering, vector design, quality attribute generation, and functional characterization of biotherapeutics. The candidate will have additional opportunities to serve as representative to project teams operating within BMS’s thematic research centers.
Position Responsibilities:
- Provide laboratory leadership and management of the high-throughput production group in Cambridge from this bench facing role
- Expand group capabilities though maintaining a working knowledge a state-of-the-art approaches for high throughput production and facilitating their internal implementation
- Serve as the point of contact on across discovery biotherapeutics on high-throughput approaches for biotherapeutic production including managing requests, analyzing, communicating results, and cataloging of all data in relevant databases
- Collaborate with multiple project teams across each thematic research area to advise on key fit-for-purpose production and quality attributes of biotherapeutic purity in line with the needs of the program and stage of development
- Serve as subject matter expert in mammalian vector design for therapeutic production in high-throughput through stable cell line development activities
- Enable the timely progression of BMS's discovery pipeline
- Collaborate with cross functional project drive the discovery and development of next-generation biotherapeutics
- Independently conceive and execute novel approaches for high-throughput production of biotherapeutics
- Prepare and present data and updates to project and functional teams, official reports and SOPs for internal and external purposes, internal documents/reports for regulatory filings
- Manage lab/equipment organization and maintenance.
- Coordinate and serve as point of contact for CROs in outsourced workflows for gene synthesis
Basic Qualifications:
Bachelor’s Degree with 8+ years of academic / industry experience
Or
Master’s Degree with 6+ years of academic / industry experience
Or
PhD with 4+ years of academic / industry experience
Preferred Qualifications:
- PhD and 4+ years of expertise in theory, equipment, and implementation of high throughput approaches for production of monoclonal antibodies, multispecifics and other modalities is essential
- Experience in successfully supporting a robust biotherapeutic production pipeline through various roles in protein production and/or analytics including HPLC and LCMS approaches is desired
- Previous experience managing teams engaged in pipeline support is critical for the successful candidate
- Hand-on experience with high throughput molecular biology methods, cloning, plasmid preparation, vector design, PCR, mutagenesis, and DNA sequence analysis is highly desirable
- Familiarity with sequence based, structure based, and predictive approaches for protein design of therapeutics and antigens is desirable
- Must be very detail-oriented and organized, with excellent time-management and multitasking skills to enable work on multiple pipeline projects
- Have outstanding analytic and problem-solving abilities
- Display excellent verbal and written communication, interpersonal and presentation skills, as well as the ability to interact tactfully and effectively with employees at all levels of the organizational structure
- Must be highly self-motivated, detail-oriented, well organized and work effectively as part of a team
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Drug Discovery Research
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
We are seeking an energetic and versatile protein engineer to join our Protein Engineering group in Cambridge, MA in a lab-facing role. The ideal candidate is a scientific innovator with a deep understanding of protein structure and antibody engineering and a track record of implementing creative approaches to developing novel protein biotherapeutics. The successful candidate will contribute to the strategy of biotherapeutic design and utilize their hands-on experiences to drive the successful implementation of these designs in multidisciplinary project teams. This protein engineer will contribute to technological solutions for the production and screening of multispecific therapeutics through collaborations within the broader Discovery Biotherapeutic community at BMS. This is an ideal position for an experienced protein engineer who is enthusiastic about deploying creative solutions to design a wide range of protein therapeutic modalities for the treatment of a diverse set of diseases.
Basic Qualifications
Bachelor's Degree with 7+ years of academic / industry experience
Or
Master's Degree with 5+ years of academic / industry experience
Or
PhD in Biology with 2+ years of academic / industry experience
Desired skills and experiences
- PhD in structural biology, biochemistry, or a closely related field
- Deep understanding of protein structure and function relationships is required
- Experience in structure-based engineering of proteins to match modality to biological function and improve protein attributes such as activity, yield, and developability
- Diverse hands-on experiences including protein expression and purification (affinity, ion exchange, size exclusion, and mixed-mode chromatography)
- Experience in analysis of biotherapeutics beyond monoclonal antibodies is essential
- Fluency with generating and applying computational predictions and structural analysis in drug discovery projects (e.g. Schrodinger, MOE, and/or Rosetta)
- Must be highly self-motivated, detail-oriented, and well organized
- Experience with high-throughput methods of cloning, production, and analysis of multispecific therapeutics is preferred
- Proven record of active participation in team-based drug discovery in a pharmaceutical or biotechnology environment is preferred
- Excellent written and verbal presentation skills as evidenced through external publication and presentation
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Drug Discovery Research
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS.
We are looking for an experienced, collaborative, highly motivated scientist and leader with deep expertise in antibody drug conjugates (ADC) technologies. The candidate should have deep understanding and experience antibody drug conjugation technologies. The candidate is expected to have strong collaborative skills to ensure robust partnerships with biologists, antibody discovery and engineering & bioanalytical scientists to advance ADC projects.
A prove track record of hands-on experience with antibody-drug conjugation chemistry, analytical characterization and developability of ADCs is a must have for this position.
Responsibilities:
- The role will involve leading and carrying out laboratory experiments related to ADC conjugation, associated purification and analytical characterization of the conjugates
- Design, produce, and characterize antibody-drug conjugates (ADCs) with a high degree of independence
- Proactively advise and share knowledge and expert opinions with bench scientists, peers and senior management. Mentor staff in troubleshooting strategic and experimental issues
- Record of leading project teams through different stages of pre-clinical discovery
- Ensure highest standard of quality in antibody-conjugate productions in alignment with product development guidelines and QC criteria
- Collaborate with a diverse team of biologists and chemists to answer scientific questions and drive forward new conjugation platforms
- Leverage knowledge of bioconjugation and protein engineering to develop new therapeutic ADC technologies.
- The candidate will encourage ideas for continuous improvement activities & new technology development and initiative within work group.
- Contribute to patents, publications, and technical reports.
Basic Qualifications:
Bachelor’s Degree with 8+ years of academic or industry experience
Or
Master’s Degree with 6+ years of academic or industry experience
Or
PhD with 4+ years of academic or industry experience
Preferred Qualifications:
A PhD with 4+ years of industry experience
Extensive hands-on experience with therapeutic antibody and ADC discovery
Deep knowledge of bioconjugation chemistries (lysine, inter-chain cysteine and/or site-specific cysteine and other) is needed.
Experience in development of purification strategies using various chromatographic techniques such as affinity, size exclusion, ion-exchange, hydrophobic interaction, and tangential flow filtration (TFF)
Experience in analytical characterization of ADCs including SEC, RP-HPLC, LC-MS, CE-SDS, ELISA, DSC, and HIC
Experience with biological assays such as measuring cytotoxic activity for ADC characterization.
Hands-on experience with siRNA/ASO conjugations and analytics is a plus.
Demonstrated record of scientific accomplishments and publications.
Excellent written and oral communication skills and ability to interpret results and contribute to multidisciplinary biologics discovery teams
For California Sites - The starting compensation for this job is a range from $121,000 – $167,200, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Drug Discovery Research
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
As part of the Discovery Biotherapeutics efforts at BMS, the Senior Director of Protein Engineering will play a key role in discovering and delivering a first-in-class and best-in-class Biotherapeutics pipeline.
The Senior Director, Protein Engineering, will be responsible for leading a team of 20+ scientists across three Bristol Myers Squibb (BMS) sites located in Cambridge (MA), San Diego (CA), and the San Francisco Bay Area (CA). The primary responsibility will be to design, engineer, and characterize biologic drug candidates, including antibody drug conjugates, bispecific and multi-specific antibodies, and other biomolecule formats to progress BMS’s robust pipeline that spans multiple disease areas including oncology, hematology, immunology, neuroscience, and cardiovascular disease. The Senior Director, Protein Engineering, role will be crucial in innovating and advancing protein engineering capabilities, supporting drug development initiatives, and ensuring the success of BMS's research activities.
You will work in close collaboration with scientific leaders across the global Research organization and beyond (e.g., Biologics Drug Product/CMC teams) to deliver on our Biologics pipeline. You must have a thorough understanding of biologics modalities with an appreciation of the requirements and processes needed to advance biologics programs (including novel formats) through discovery and into development. A proven track record of establishing and/or using cutting edge protein engineering technologies (either internal or external) to progress an innovative biologics pipeline is key.
Responsibilities:
- Lead and drive innovation in protein engineering and core platform processes.
- Manage resources for protein design and production to support new drug development technologies and research initiatives.
- Engineer biotherapeutic modalities, including novel formats, identifying, and mitigating risks in protein engineering projects.
- Utilize structural and sequence analysis to guide the design of drug candidates.
- Oversee the optimization, quality validation, and stability studies of drug candidates.
- Make clear and impactful data-driven recommendation on programs.
- Contribute to regulatory filings of biotherapeutics.
- Prepare reports, papers, and patent applications in collaboration with cross-functional scientists and other functional areas.
- Drive timeline planning and decision-making regarding research priorities and project feasibility.
- Manage group budgets, allocate resources efficiently, and ensure cost-effectiveness.
- Lead, mentor, and develop a high-performing team, fostering innovation, collaboration, and continuous learning.
- Engage in strategic planning, setting research priorities, and advancing drug development pipelines, driving continuous improvement.
- Oversee multiple projects, set timelines, and ensure timely delivery of objectives.
- Represent the company externally, engage with key opinion leaders, and present at external scientific meetings.
- Additional responsibilities may include oversee and implement automation for high-throughput plate-based cloning, expression, and purification of biologic drug candidates.
Basic Qualifications:
Bachelor’s Degree with 15+ years of academic / industry experience
Or
Master’s Degree with 12+ years of academic /industry experience
Or
Ph.D with 10+ years of academic / industry experience
And 8+ years of leadership experience
Preferred Qualifications:
- A Ph.D. in Biochemistry, Biotechnology, Molecular Biology, or a related field.
- 10-15 years of increasing responsibilities and experience in protein engineering, preferably with industry experience.
- Demonstrated leadership and people management skills, with the ability to effectively lead and manage teams.
- Strong strategic vision and experience in developing and executing strategic plans that align with organizational goals.
- Excellent analytical and problem-solving skills, with the ability to identify challenges and propose innovative solutions.
- Exceptional communication and collaboration skills, with the ability to effectively interact with cross-functional teams and stakeholders at all levels.
- Track record of scientific publications and presentation at meetings, or authorship of patents, regulatory documents.
These qualifications and responsibilities will enable the Senior Director, Protein Engineering, to successfully lead the protein engineering teams across multiple sites, drive innovation, and contribute to the success of drug development initiatives at BMS.
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
Position Summary:
The TAS is a critical role in our unique customer model to execute the BMS aspiration to be the BioPharma that delivers the most impactful engagement with Health Care Providers (HCPs), driving adoption of new and existing medicines for appropriate patients.
The primary role of the TAS is to drive demand for BMS medicines within their portfolio for the appropriate patients. To meet the HCPs expectations, the TAS engages them with a differentiated Customer Experience (Cx) through deeper scientific dialogue on and consistent with label, leveraging new ways of working and CE^3.
The role builds and maintains strong professional credibility with regional thought leaders (RTLs) and community-based physicians/HCPs in private practice, medical groups practices, office staff, and other stakeholders in the patient care continuum as their primary point of contact.
The TAS liaises with other BMS functions as needed to deliver an overall higher Customer Experience (Cx) – by meeting HCP needs in a timely and scientific manner. This role will prioritize the safe and appropriate use of BMS products while also focusing on overall business results and performance objectives while exemplifying BMS values.
The TAS role is field-based. A TAS is anticipated to spend 100% of their time in the field with external customers.
Key Responsibilities:
Portfolio Promotion
- Promotes approved indications of BMS products and the launch of KarXT (xanomeline-trospium) within a defined territory or region to meet or exceed assigned sales targets in a compliant manner.
- Creates demand for BMS medicines by articulating in a balanced manner the clinical and scientific rationale for use of products in appropriate patients.
- Engages with and continuously maintains/grows a high level of scientific expertise in all assigned products and therapeutic areas.
- Prepares and successfully implements comprehensive territory and account plans.
- Proactively uses available tools such as CE^3 (once implemented) to derive insights and to dynamically inform call plans. Provides feedback on experience using these tools to leadership to enable continuous improvement.
Fair & Balanced Scientific Dialogue
- Demonstrates scientific expertise and passion in using approved scientific resources and publications to present information to HCPs and ensures medical accuracy.
- Conducts in-office presentations (e.g., lunch and learns) and discusses product-related scientific information with HCPs that is consistent with label.
- Organizes external speaker programs, selecting speakers from list approved by Speakers Bureau and facilitating scheduling and logistics.
- Maintains a high level of working expertise on emerging data for approved indications.
- Engages real-time medical support through Medical on Call to reactively answer unsolicited questions and complex technical inquiries.
Cross-functional collaboration
- Proactively collaborates with other field teams to ensure the best Customer Experience (Cx) for HCPs.
- Gathers and shares relevant insights and information internally with the appropriate stakeholders to enable BMS to better serve its customers.
Complies with all laws, regulations, and policies that govern the conduct of BMS.
Required Qualifications & Experience:
- Advanced scientific degree and/or preferred 5+ years of pharmaceutical or biotechnology experience as healthcare sales / MSL / HCP / nurse.
- Ability to communicate scientific or clinical data accurately and convincingly to help physicians best serve their patients.
- Demonstrated experience building and maintaining strong credibility with key customers, office staff, and others in the customer influence network via a customer-centric mindset and desire to create positive and differentiated Customer Experience (Cx).
- Experience in Neuropsychiatry is preferred.
- Demonstrated strong capability in account management skill sets, superior selling competencies, and proven sales performance track record of meeting or exceeding goals.
- Demonstrated ability to work effectively cross-functionally with a positive team mindset and can-do attitude.
- Strong selling and promotional skills proven through a track record of performance.
Key Competencies Desired:
Customer/commercial mindset
- Demonstrated ability to drive business results.
- Experience identifying, engaging, and cultivating credibility with customers across the patient care journey.
- Demonstrated account management skills and problem-solving mentality. Understands the patient journey and can customize engagement and deliver tailored messages.
- Demonstrated resourcefulness and ability to connect with customers.
Patient centricity
- Understands the patient journey and experience.
- Has a patient-focused mindset.
Scientific Agility
- Excellent communication and presentation skills to articulate scientific and clinical data in an easy-to-understand manner to help HCPs best serve their patients.
- Has a strong learning mindset and passion for science. Prioritizes staying current with the latest data.
Analytical Capability:
- Ability to analyze data, such as prescribing patterns, market trends, and HCP preferences. Data-driven insights help TAS strategize and target their efforts effectively.
- Ability to segment HCPs based on their preferences and other relevant factors. This helps them tailor their communication and product presentations to suit individual HCP needs.
- Understanding how to interpret and analyze data related to BMS products, customer preferences, clinical data.
- Ability to use CE^3 to generate insights and do dynamic call planning.
Technological Agility:
- Understanding, adapting, and effectively using technology in various aspects of healthcare business and interacting with HCPs.
- Utilizing various digital communication channels such as emails, instant messaging apps, and video conferencing to stay in touch with healthcare professionals, colleagues, and clients. This enables TAS to respond promptly to inquiries, share updates, and maintain effective communication.
- Competency using CE^3 and other software or CRM tools to collect, enter, and manage quality data in a timely and compliant manner, track interactions, and plan future engagements with healthcare professionals.
- Ability to use the Medical on Call technology effectively.
- Being able to navigate and utilize the internet and online resources effectively.
- Keeping up to date with technological advancements and changes.
Teamwork/Enterprise mindset
- Strong business acumen to understand and analyze business and market drivers and develop, execute, and adjust business plans.
- Demonstrates a strong sense of learning agility. Seeks out and learns from unfamiliar experiences, and then applies those lessons to achieve better results in subsequent situations.
- Track record of balancing individual drive and collaborative attitude.
- Holds a high level of integrity and good judgment, in order to navigate the requirements of the role effectively and compliantly in accordance with BMS policies and procedures.
As this position requires the operation of a Company-provided vehicle, offers of employment are contingent upon the candidate meeting the requirements of “Qualified Driver,” as determined by the Company in its sole discretion, including but not limited to the following: 1) at least 21 years of age; 2) a driver’s license in good standing issued by your state of residence; and, 3) a driving risk level deemed acceptable by the Company.
#LI-Remote and #BMSNEURO
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Drug Discovery Research
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
Director Protein Production and Quality Attributes (San Diego, California, USA)
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.
As part of the Discovery Biotherapeutics team at BMS, the Director of Protein Production and Quality Attributes will play a key role in supporting the delivery of a first-in-class and best-in-class biotherapeutics pipeline. The incumbent will be responsible for leading a team of about 25 scientists across two BMS sites located in San Diego (CA) and Cambridge (MA). The primary responsibilities include managing a cross-site and cross-functional team focused on the production and characterization of monoclonal antibodies, multi-specifics, antibody-drug conjugates (ADCs), and other protein therapeutics using state-of-the-art technology and an industry-competitive DNA-to-protein production process. The Director role will be crucial in innovating and advancing Discovery Biotherapeutics function capabilities, supporting drug development initiatives, and ensuring the success of BMS's research activities.
You will work in close collaboration with scientific leaders across the global Research organization and beyond (e.g., Biologics Drug Product/CMC teams) to deliver on our biologics pipeline. You must have a thorough understanding of biologics modalities production end-to-end (i.e., from cloning to purification and quality analyses) in high-throughput, mid, and large-scale settings, with documented experience of the requirements and processes needed to advance biologics programs (including novel formats) through discovery and into development. A proven track record of establishing and/or using cutting-edge protein cloning, production, and purification technologies to progress an innovative biologics pipeline is key.
Responsibilities:
- Manage, mentor, and develop a high-performing team (consisting of PhD and non-PhD scientists) dedicated to excellence in biologics cloning, production, purification with a focus on strategic goal setting and talent management.
- Apply deep scientific knowledge of protein production, concepts, and methodologies to deliver on biotherapeutics pipeline in alignment with Discovery Biotherapeutics, including being point person for interactions with CMC colleagues.
- Manage high-throughput, medium, and large-scale production of biologics end-to-end (i.e., from cloning to production, purification, and formulation).
- Advance cloning and purification platforms to produce and characterize monoclonal and bispecific antibodies, fusion proteins, and ADCs.
- Apply protein structural and biophysical principles to optimize the production and manufacturability of therapeutic candidates.
- Identify and implement new technologies, applications, and external collaborations to support research goals including participating in licensing and technology evaluation of platforms as relate to the job function.
- Interface with technology providers to keep on par with industry leading protein cloning, production, purification, and manufacturability.
- Foster a continuous improvement mentality to drive platform development in terms of speed, quality, and robustness, ensuring global biologics remain aligned with industrial standards.
- Integrate analytical characterization data to optimize biologics production.
- Ensure clear communication among team members and across teams to foster a culture of proactive collaboration and engagement.
Basic Qualifications:
Bachelor's Degree with 15+ years of academic / industry experience
or
Master's Degree with 12+ years of academic / industry experience
or
PhD with 8+ years of academic / industry experience with 6+ years leadership experience.
Preferred Qualifications:
- A Ph.D. in Biochemistry, Biotechnology, Molecular Biology, or a related field
- 10+ years of increasing responsibilities and experience in protein cloning, production, purification, and quality analyses, preferably in an industry setting.
- Demonstrated leadership and people management skills, with the ability to effectively lead and manage teams.
- Strong strategic vision and experience in developing and executing strategic plans that align with organizational goals.
- Excellent analytical and problem-solving skills, with the ability to identify challenges and propose innovative solutions.
- Exceptional communication and collaboration skills, with the ability to effectively interact with cross-functional teams and stakeholders at all levels.
- Hands-on experience with CHO and other mammalian cells for mAb or recombinant protein production is a must.
- Experience in tech transfer, including drafting reports, protocols, and knowledge for process transfer.
- Demonstrated ability to successfully and efficiently coordinate multiple work streams and projects simultaneous.
- Track record of scientific publications and presentations at meetings, or authorship of patents and regulatory documents.
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
Drug Dev and Preclinical Studies
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
Summary/Scope
Responsible for the development and implementation of the model-informed drug development (MIDD) plan for drugs and other therapeutic agents in clinical development, in partnership with the CP&P Lead for the asset.
MIDD has emerged as a powerful complement to conventional drug development whereby pharmacometric (PMx: pharmacokinetic, exposure-response, and disease progression) models are developed with data from a variety of sources are utilized to inform drug development decisions and regulatory assessments. MIDD informs dose and regimen selection and hypotheses to be investigated in clinical studies; and supports regulatory assessments of the clinical pharmacology, and benefit-risk profile of a therapeutic agent by complementing data from clinical studies. Additionally, PMx analyses may also inform approval decisions, and in some cases be the primary basis for the approval.
Responsibilities will include, but are not limited to, the following:
Partners with CP&P Lead to specify MIDD components of CP&P plan, with supervision
Supports CP&P Lead in planning, executing, and reporting of exploratory PMx analyses in support of drug development decisions, with supervision
Responsible for planning, executing, and reporting on formal PMx analyses included in CSRs, HA submissions, and responses to questions from HAs, with supervision
Serves as MIDD SME, and supports CP&P lead in the development of therapeutic agents, with supervision
Contributes to maintenance and refinement of PMx infrastructure, with supervision
Contributes to CP&P initiatives
Skills/Knowledge Required
For Sr. Research Investigator we require Ph.D or PharmD. in relevant field with 2+ years experience hands on Pharmacometrics experience in industry, or hands on Post Doctoral Fellowship in Pharmacometrics activities may be considered. OR Masters Degree with 7 years Pharmacometrics experience required.
For Research Investigator level we require Ph.D.or PharmD in relevant field with 0-2 years Pharmacometrics experience in industry or hands on Ph.D Program OR Masters Degree with 5 years Pharmacometrics experience required.
Basic quantitative data analysis, Data wrangling (merging and transforming data), visualization, basic PPK and E-R are all highly desired
Programming experience is highly desired (e.g., R and NLME software such as NONMEM or Monolix)
Knowledge of current practices and issues in Clinical Pharmacology and Pharmacometrics
Strong written and oral communication skills necessary to report on and deliver scientific presentations
Demonstrated ability to work in a dynamic team-oriented environment
#LI-Hybrid
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.