Job Details

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Bioanalytical (BA) function within Precision Medicine, Bioanalytical & Translational Sciences (PMBATS) is a centralized function for testing biological samples for Pharmacokinetics (PK), biomarkers, and Immunogenicity assessments. The responsibilities of the groups include providing bioanalytical and biomarker leadership on BMS drug development teams via scientific/technical expertise and strategic input; overseeing and/or performing assay development/ validation, and sample analysis; supporting regulated and non-regulated bioanalysis/biomarker analysis for toxicology and clinical studies; and preparing appropriate documentation and/or interacting with health authorities on the bioanalytical/biomarker components of regulatory filings. The BA groups utilize both internal resources and external strategic partners to ensure on-time delivery of BA and biomarker data to enable key decisions for the organization.

The candidate for this position has the responsivities of evaluating and de-risking methods from the discovery to development stages using tandem/high resolution mass spectrometry. The individual will provide leadership in BA/biomarker method development and study support for development compounds from various modalities (e.g., small molecules, large molecule therapeutics, etc.). In addition, the candidate will play a critical role as an expert in evaluating advanced laboratory equipment. There are also opportunities for development to act as a BA or biomarker lead on cross-functional study teams, collaborating to address bioanalytical and biomarker-related challenges. 

Key Responsibilities

• Evaluate and implement innovative techniques or methodologies to tackle complex bioanalytical and biomarker challenges.
• Conduct in-house bioanalytical and biomarker support for exploratory/development programs with tandem/high resolution mass spectrometry-based method development, method troubleshooting, sample analysis, data interpretation, and report preparation.
• Serve as the technical expert in sample cleanup, chromatography, mass spectrometric instrumentation, and stability assessments.
• Interact with bioanalytical/biomarker CROs to resolve method-related issues and provide leadership in the knowledge transfer of novel technologies.
• Keep management apprised of project status and current scientific trends using written and oral summaries, as well as presentations.

Basic Qualifications

• Ph.D. or equivalent advanced degree in the Life Sciences
  • 2+ of academic and / or industry experience

• Preferred candidate will have a degree in chemistry, biochemistry, biology, proteomics or metabolomics related fields, plus relevant drug development experience at either a pharmaceutical company or a bioanalytical & biomarker CRO.
• A good understanding of bioanalysis & biomarkers and their roles in drug development, including method development, fit-for-purpose validation, study support, and the impact of quality bioanalytical/biomarker data on PK/PD correlation.
• Strong LC-MS/MS (Sciex 6500 and 7500) and LC-HRMS (Thermo Q Exactive or Sciex ZenoTOF 7600) skills including separation and quantitation (or identification) of small molecules (e.g. chiral assay) or large molecule therapeutics (e.g. hybrid assays for ADC quantitation and PTM identification) and biomarkers (e.g. small molecule/protein assays) in biological matrices. A strong foundation and experience in using, maintaining, and troubleshooting mass spectrometers is preferred.
• Hands on experience with various PK/biomarker sample clean-up technologies, such as PPT, SPE, SLE for small molecule analytes, as well as immuno-capture with bead or cartridge formats and enzymatic digestion for protein therapeutics and protein biomarkers.
• A proven track record of method development accomplishments in the field (through presentations or publications).
• Good communication skills and experience in authoring and reviewing bioanalytical & biomarker assays, troubleshooting assay issues.

• Experience in performing LC-MS/MS and LC-HRMS method development, qualification (or validation) and study sample analysis in a regulated environment.
• Ability to multi-task and work in a collaborative team environment.
• Ability to communicate effectively in a team-based environment.

Location
Princeton - NJ - US

On-site Protocol
BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

#LI-ONSITE

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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