Job Details

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases. 

Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis.  Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro.   LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency.  Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology.  The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate.  Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

Scientist - Cellular pharmacology– Lead Discovery & Optimization, San Diego, CA 

The Lead Discovery and Optimization Group within Small Molecule Drug Discovery in San Diego focuses on delivering novel therapeutics for disease intervention by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a Scientist to identify and characterize small molecule drug candidates for the treatment of human diseases. The successful candidate will work collaboratively in a multi-disciplinary environment to carry out cell-based assays in support of small molecule discovery for pre-clinical development.

Responsibilities:

• Be responsible for technology innovation for high-throughput screening platforms as well as expand targeted protein degradation and proximity based assay platforms for E3 ligases.
• Develop innovative cellular and/or biochemical assays to discover and validate on target protein degradation and neosubstrate specificity.
• Bring strategic insight into program support ensuring robust and innovative solutions and approaches towards the development of cell based assays for screening, hit triage, SAR, and MOA.
• Possess strong collaborative and written/verbal communication skills and a positive attitude to interact with multiple stakeholders across different departments and research sites.
• Highly motivated self-starter who can work independently and be multi-tasking in a fast-paced team.
• Contribute to the writing of investigator brochures, IND applications, and other regulatory documents when appropriate.
• Demonstrate strong analytical and critical thinking skills with the ability to interpret complex data.

Basic Qualifications:

Bachelor's Degree 5+ years of academic / industry experience

or

Master's Degree 3+ years of academic / industry experience

or

PhD No experience required

Preferred Qualifications:

• PhD in Cell Biology, Molecular Biology, or Biochemistry, or MS with 3+ or BS with 5+ years experiences in academia or biopharmaceutical industry
• Experience in ubiquitin proteasome system (UPS) and E3 ubiquitin ligases is highly essential.
• Superior assay design and high-throughput screening skills in cell-based assay formats as well as experience in the application of modern technology are preferred.
• Relevant skills include proficiency in cell-based/biochemical assay development such as AlphaLISA, ELISA, HTRF, MSD, immunoblot, high content image, FACS and qPCR.
• Ability to create and maintain an effective scientific network through teamwork, excellent problem solving skills and open collaborative style are of critical importance to the success of this role. 

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.