Neoantigens
What are neoantigens? Neoantigens are newly formed antigens that have not been previously recognized by the immune system. Neoantigens can arise from altered tumor proteins formed as a result of tumor mutations or from viral proteins.1
How is neoantigenicity measured? The number of neoantigens in a tumor genome can be measured by next-generation sequencing. Neoantigen prediction algorithms have been developed to identify which neoantigens will likely solicit an immune response.1,2
Why are neoantigens important? Tumor antigens may be recognized by the immune system as non-self and elicit an immune response. Tumors with high TMB and/or MSI-H/dMMR may lead to an increase in neoantigens.3-6