Researchers are investigating ways to increase brain endocannabinoids to restore them to normal levels. This may reduce neuronal hyperexcitability and possibly protect brain cells from the harmful effects of neuroinflammation.
One method to achieve this may be to inhibit the enzymatic activity of FAAH and MAGL. Research suggests inhibiting both of these enzymes reduces the breakdown of endocannabinoids, facilitating signaling via their receptors and controlling neuronal hyperexcitability. This modulation of the endogenous endocannabinoid system could improve functional outcomes associated with multiple neurological conditions.
In addition, inhibiting FAAH and MAGL may also reduce neuroinflammation, thus contributing to neuroprotection.10,11