In the Pipeline
Bristol-Myers Squibb’s pipeline is one of the most innovative in the industry. Learn more about the medicines we are developing.
|
Exploratory Development
(Preclinical, Phase I, Phase II) |
Full Development (Registrational, Filed) |
Marketed Product Development |
| IGF-1R antagonist (cancer) |
Ipilimumab (cancer) |
IXEMPRA® (ixabepilone) (cancer) |
| VEGF R-2 Adnectin inhibitor (cancer) |
Brivanib (cancer) |
SPRYCEL® (dasatinib)
(cancer) |
| ErbB/VEGF inhibitor (cancer) |
Tanespimycin (cancer) |
ERBITUX®(cetuximab)
(cancer) |
| Anti-CD137 antibody (cancer) |
XL-184 (cancer) |
ORENCIA® (abatacept) (rheumatoid arthritis) |
| Epothilone-Folate (cancer) |
Belatacept (solid organ transplant) |
PLAVIX® (clopidogrel bisulfate tablets) (atherothrombosis) |
| SMO inhibitor (cancer) |
ONGLYZA™ (saxagliptin) (diabetes) |
AVAPRO® (irbesartan) AVALIDE® (irbesartan-
hydrochlorothiazide) (hypertension) |
| Cdc7 inhibitor (cancer) |
Dapagliflozin (diabetes) |
ABILIFY® (aripiprazole) (psychiatric disorders) |
| Anti-CS1 antibody (cancer) |
Apixaban (thrombosis) |
BARACLUDE®(entecavir) (hepatitis B) |
| Adnectin Bispecific inhibitor (cancer) |
|
REYATAZ® (atazanavir sulfate) (HIV/AIDS) |
| RAF Kinase inhibitor (cancer) |
|
SUSTIVA® (efavirenz) ATRIPLA® (efavirenz / emtricitabine / tenofovir disoproxil fumarate) (HIV/AIDS) |
| p38 Kinase inhibitors (rheumatoid arthritis) |
|
|
| CCR1 antagonist(rheumatoid arthritis) |
|
|
| GR agonists (immunology) |
|
|
| S1P1 agonist (immunology) |
|
|
| 11βHSD inhibitors (diabetes) |
|
|
| Glucokinase activator (diabetes) |
|
|
| MCHR1 (obesity) |
|
|
| CCR2 antagonist (CV / Met) |
|
|
| DGAT inhibitor (CV / Met) |
|
|
| LXR agonists (atherosclerosis) |
|
|
| PCSK9 inhibitor (cardiovascular) |
|
|
| CCR2/CCR5 antagonist(cardiovascular) |
|
|
| Delta PKC inhibitor (cardiovascular) |
|
|
| IKACh inhibitor (cardiovascular) |
|
|
| Triple Reuptake inhibitors (depression) |
|
|
| Gamma Secretase inhibitor (alzheimer’s) |
|
|
| HCV NS5A inhibitors (hepatitis C) |
|
|
| HCV NS3 Protease inhibitor (hepatitis C) |
|
|
| HCV NS5B Replicase inhibitor (hepatitis C) |
|
|
| PEG-Interferon Lambda (hepatitis C) |
|
|
| HIV Attachment inhibitor (HIV/AIDS) |
|
|
|
Please click on product name to see the Full Prescribing Information for ABILIFY®, ATRIPLA®, AVAPRO®/AVALIDE®, BARACLUDE®, ERBITUX®, IXEMPRA®, ONGLYZA™, ORENCIA®, PLAVIX®, REYATAZ®, SPRYCEL®, SUSTIVA®, including boxed WARNINGS for ABILIFY®, ATRIPLA®, BARACLUDE®, ERBITUX®, IXEMPRA™, and TAXOL®, and boxed WARNINGS for AVAPRO® and AVALIDE® regarding use in pregnancy. As soon as pregnancy is detected, discontinue use of AVAPRO® or AVALIDE®.
Full Development compounds are investigational drugs that are in late-stage clinical development, or have been submitted to regulatory agencies for approval.
Marketed Product Development compounds have been approved in at least one major market and are among approved medicines that are driving current and future growth while continuing their clinical development to determine whether additional indications and formulations will benefit patients. Current medicines in marketed product development include treatments in the areas of cardiovascular disease, HIV/AIDS, psychiatric disorders, rheumatoid arthritis, cancer and virology.
Like any other scientific endeavor, clinical testing of novel drug compounds is a complex, time-consuming, resource-intensive process with no guaranteed results. But, as described here, Bristol-Myers Squibb is committed to pursuing such clinical development and, in doing so, to bringing new hope to patients.